Favourable effect of clavulanic acid on the minimum inhibitory concentrations of cefixime and ceftibuten in ESBL-producing Escherichia coli and Klebsiella pneumoniae.
J Glob Antimicrob Resist
; 38: 212-215, 2024 Sep.
Article
em En
| MEDLINE
| ID: mdl-38945364
ABSTRACT
OBJECTIVES:
The use of cephalosporins combined with clavulanate for the treatment of ESBL-harbouring Enterobacteriaceae has been scarcely described. We aimed to describe the effect of different concentrations of clavulanate in the MIC of cefixime and ceftibuten of ESBL-producing Escherichia coli and Klebsiella pneumoniae.METHODS:
ESBL-producing E. coli and K. pneumoniae isolates were studied. Fixed concentrations of cefixime and ceftibuten (ranges of 32-0.25 and 64-0.5 ng/ml, respectively) were used. Combinations of cefixime/clavulanate and ceftibuten/clavulanate in different ratios (10, 11, 21, 41, 81, 161, 321) were tested. MIC were determined by broth microdilution.RESULTS:
A total of 6 ESBL-producing E. coli, 6 ESBL-producing K. pneumoniae and 2 control E. coli were tested. When different quantities of clavulanate were added to cefixime and ceftibuten, greater than two-fold decreases in the MIC were observed. When testing the 11 cefixime/clavulanate ratio, 10/12 isolates were susceptible. When the ratios 21, 41, 81 and 161 were tested, susceptibility was noted for 9/12, 8/12, 4/12 and 5/12 isolates, respectively. Only 2/12 K. pneumoniae isolates were susceptible when the ratio 321 was tested. When testing ceftibuten/clavulanate, all isolates remained susceptible across all experiments.CONCLUSIONS:
Clavulanic acid has a favourable effect in reducing the MIC of cefixime and ceftibuten in isolates of ESBL-producing E. coli and K. pneumoniae. Combining clavulanate with ceftibuten or cefixime could be a useful treatment strategy.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Beta-Lactamases
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Testes de Sensibilidade Microbiana
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Ácido Clavulânico
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Cefixima
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Escherichia coli
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Ceftibuteno
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Klebsiella pneumoniae
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Antibacterianos
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article