Vascular syk-ness: A new role for an old immunological favorite.
J Biol Chem
; 300(7): 107517, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-38945448
ABSTRACT
Acute respiratory distress syndrome (ARDS) is a deadly clinical presentation in sepsis, COVID, and other lung disorders where vascular fluid leakage is a severe problem. Recent findings by Shadab et al. in the JBC show that a well-known player in immune function, Syk, also regulates vascular leakage in response to sepsis. An existing FDA-approved inhibitor of Syk, fostamatinib, prevents the vascular leakage and improves survival in a mouse sepsis model, providing promise for ARDS treatment in the clinic.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pirimidinas
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Síndrome do Desconforto Respiratório
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Morfolinas
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Inibidores de Proteínas Quinases
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Quinase Syk
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Aminopiridinas
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article