[Latest Findings on the Role of α-Ketoglutarate in Metabolic Syndrome]. / α-é
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Sichuan Da Xue Xue Bao Yi Xue Ban
; 55(3): 783-792, 2024 May 20.
Article
em Zh
| MEDLINE
| ID: mdl-38948289
ABSTRACT
Alpha-ketoglutarate (α-KG), an endogenous intermediate of the tricarboxylic acid cycle, is involved in a variety of cellular metabolic pathways. It serves as an energy donor, a precursor of amino acid biosynthesis, and an epigenetic regulator. α-KG plays physiological functions in immune regulation, oxidative stress, and anti-aging as well. In recent years, it has been reported that the level of α-KG in the body is closely associated with metabolic syndrome, including obesity, hyperglycemia, and other pathological factors. Exogenous supplementation of α-KG improves obesity, blood glucose levels, and cardiovascular disease risks associated with metabolic syndrome. Furthermore, α-KG regulates the common pathological mechanisms of metabolic syndrome, suggesting the potential application prospect of α-KG in metabolic syndrome. In order to provide a theoretical basis for further exploration of the application of α-KG in metabolic syndrome, we focused on α-KG and metabolic syndrome in this article and summarized the latest research progress in the role of α-KG in improving the pathological condition and disease progression of metabolic syndrome. For the next step, researchers may focus on the co-pathogenesis of metabolic syndrome and investigate whether α-KG can be used to achieve the therapeutic goal of "homotherapy for heteropathy" in the treatment of metabolic syndrome.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Síndrome Metabólica
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Ácidos Cetoglutáricos
Limite:
Animals
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Humans
Idioma:
Zh
Ano de publicação:
2024
Tipo de documento:
Article