DRD4 gene polymorphism and impulse control disorder induced by dopamine agonists in Parkinson's disease.
Ann Clin Transl Neurol
; 2024 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-38952083
ABSTRACT
Impulse control disorders and their consequences display variability among individuals, indicating potential involvement of environmental and genetic factors. In this retrospective study, we analyzed a cohort of Parkinson's disease patients treated with dopamine agonists and investigated the influence of the dopamine D4 receptor gene polymorphism, DRD4 7R+, which is linked to psychiatric disorders, impulsive traits, and addictive behaviors. We found that DRD4 7R+ is a significant genetic risk factor associated with the severity of ICD.
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MEDLINE
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En
Ano de publicação:
2024
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Article