Antiplatelet and Antithrombotic Properties of Compound L-36, a 6H-1,3,4-Thiadiazine Derivative.
Bull Exp Biol Med
; 177(1): 63-67, 2024 May.
Article
em En
| MEDLINE
| ID: mdl-38954300
ABSTRACT
Compound L-36, a new derivative of 6H-1,3,4-thiadiazine, was studied in in vitro and in vivo experiments. This compound exhibits high antiplatelet and antithrombogenic activity. In in vitro experiments, compound L-36 by its antiplatelet activity (by IC50) was superior to acetylsalicylic acid by 9.4 times. In in vivo experiments, compound L-36 by its ED50 value was close to the comparison drug. On the model of pulmonary artery thrombosis, compound L-36 ensured better survival of experimental animals than acetylsalicylic acid. Morphological studies showed that compound L-36 effectively attenuated the thrombosis processes in the pulmonary tissue induced by intravenous injection of a thrombogenic mixture (epinephrine and collagen).
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tiadiazinas
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Inibidores da Agregação Plaquetária
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Agregação Plaquetária
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Aspirina
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Fibrinolíticos
Limite:
Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article