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Inhalational exposure history is associated with differential sinonasal gene expression profiles and clinical outcomes in chronic rhinosinusitis patients: A pilot study.
Worden, Cameron P; Thorp, Brian D; Ebert, Charles S; Klatt-Cromwell, Cristine N; Senior, Brent A; Kimple, Adam J; Rebuli, Meghan E; Jaspers, Ilona.
Afiliação
  • Worden CP; Department of Otolaryngology-Head & Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
  • Thorp BD; Department of Otolaryngology-Head & Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
  • Ebert CS; Department of Otolaryngology-Head & Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
  • Klatt-Cromwell CN; Department of Otolaryngology-Head & Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
  • Senior BA; Department of Otolaryngology-Head & Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
  • Kimple AJ; Department of Otolaryngology-Head & Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
  • Rebuli ME; Curriculum in Toxicology and Environmental Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
  • Jaspers I; Center for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Int Forum Allergy Rhinol ; 14(10): 1652-1655, 2024 Oct.
Article em En | MEDLINE | ID: mdl-38958881
ABSTRACT
KEY POINTS Inhalational exposure (IE) history assessment is important and may guide chronic rhinosinusitis disease management. Combined exposure status was the most significant factor across differential gene expression analyse IE history was associated with pro-inflammatory transcriptome changes and worse clinical outcomes.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sinusite / Rinite / Exposição por Inalação / Transcriptoma Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sinusite / Rinite / Exposição por Inalação / Transcriptoma Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2024 Tipo de documento: Article