[CAR T-cell therapy for malignant lymphoma].
Rinsho Ketsueki
; 65(6): 536-546, 2024.
Article
em Ja
| MEDLINE
| ID: mdl-38960654
ABSTRACT
Advances in understanding of the pathogenesis of B-cell lymphoma have led to development of various novel targeted therapies. Among them, CD19-targeted chimeric antigen receptor (CAR) T-cell therapies for relapsed and refractory B-cell lymphomas have shown remarkable efficacy in clinical trials, and three CAR T-cell products are now available in Japan. Real-world evidence (RWE) has shown that these products can provide comparable efficacy to clinical trials in clinical practice, where CAR T-cells were administered in patients with wider range of backgrounds. This finding will certainly broaden the role of CAR T-cell therapies in the treatment of B-cell lymphoma. However, since about half of the patients treated with CAR T-cell therapy progress thereafter, there is an urgent need for risk stratification and optimized management of refractory cases. Here, we review the results of clinical trials and RWE of CAR T-cell therapy in B-cell lymphoma.
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Base de dados:
MEDLINE
Assunto principal:
Imunoterapia Adotiva
Limite:
Humans
Idioma:
Ja
Ano de publicação:
2024
Tipo de documento:
Article