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Association and temporal sequence of pneumonia and gastrointestinal bleeding after acute ischemic stroke.
Zhang, Runhua; Hou, Huiqing; Zhao, Xingquan; Liu, Liping; Wang, Yilong; Liu, Gaigen; Wang, Yongjun; Ji, Ruijun.
Afiliação
  • Zhang R; Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
  • Hou H; China National Clinical Research Center for Neurological Diseases, Beijing, China.
  • Zhao X; Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
  • Liu L; Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
  • Wang Y; Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China.
  • Liu G; Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
  • Wang Y; Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China.
  • Ji R; Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
BMC Gastroenterol ; 24(1): 216, 2024 Jul 05.
Article em En | MEDLINE | ID: mdl-38969973
ABSTRACT

BACKGROUND:

Stroke-associated pneumonia (SAP) and gastrointestinal bleeding (GIB) are common medical complications after stroke. The previous study suggested a strong association between SAP and GIB after stroke. However, little is known about the time sequence of SAP and GIB. In the present study, we aimed to verify the association and clarify the temporal sequence of SAP and GIB after ischemic stroke.

METHODS:

Patients with ischemic stroke from in-hospital Medical Complication after Acute Stroke study were analyzed. Data on occurrences of SAP and GIB during hospitalization and the intervals from stroke onset to diagnosis of SAP and GIB were collected. Multiple logistic regression was used to evaluate the association between SAP and GIB. Kruskal-Wallis test was used to compare the time intervals from stroke onset to diagnosis of SAP and GIB.

RESULTS:

A total of 1129 patients with ischemic stroke were included. The median length of hospitalization was 14 days. Overall, 86 patients (7.6%; 95% CI, 6.1-9.2%) developed SAP and 47 patients (4.3%; 95% CI, 3.0-5.3%) developed GIB during hospitalization. After adjusting potential confounders, SAP was significantly associated with the development of GIB after ischemic stroke (OR = 5.13; 95% CI, 2.02-13.00; P < 0.001). The median time from stroke onset to diagnosis of SAP was shorter than that of GIB after ischemic stroke (4 days vs. 5 days; P = 0.039).

CONCLUSIONS:

SAP was associated with GIB after ischemic stroke, and the onset time of SAP was earlier than that of GIB. It is imperative to take precautions to prevent GIB in stroke patients with SAP.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pneumonia / AVC Isquêmico / Hemorragia Gastrointestinal Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pneumonia / AVC Isquêmico / Hemorragia Gastrointestinal Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2024 Tipo de documento: Article