Isolation, Characterization, and Antiproliferative Activity of Terpenoids from the Tropical Plant Turraea delphinensis.
J Nat Prod
; 87(7): 1763-1777, 2024 Jul 26.
Article
em En
| MEDLINE
| ID: mdl-38970504
ABSTRACT
The isolation, structure determination, and biological evaluation of constituents from the organic extract of Turraea delphinensis Wahlert (Meliaceae) resulted in the isolation of 51 secondary metabolites, including 14 new terpenoids (six cycloartanes, four tirucallanes/euphanes, three limonoids, and a 7-keto sterol). Among the new compounds, 1 is the first triterpenoid with a trioxaspiro[4.4]nonane side chain, while 11-13 are the first 17-γ-lactone tetranortriterpenoids with four oxygenated functional groups at C-1, -3, -6, and -7. The isolated compounds were evaluated for antiproliferative activity against five human tumor cell lines, including a vinblastine-resistant cell line.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Terpenos
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Triterpenos
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Ensaios de Seleção de Medicamentos Antitumorais
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Meliaceae
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Antineoplásicos Fitogênicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article