Mitochondrial Structure, Dynamics, and Physiology: Light Microscopy to Disentangle the Network.
Annu Rev Cell Dev Biol
; 40(1): 219-240, 2024 Oct.
Article
em En
| MEDLINE
| ID: mdl-38976811
ABSTRACT
Mitochondria serve as energetic and signaling hubs of the cell This function results from the complex interplay between their structure, function, dynamics, interactions, and molecular organization. The ability to observe and quantify these properties often represents the puzzle piece critical for deciphering the mechanisms behind mitochondrial function and dysfunction. Fluorescence microscopy addresses this critical need and has become increasingly powerful with the advent of superresolution methods and context-sensitive fluorescent probes. In this review, we delve into advanced light microscopy methods and analyses for studying mitochondrial ultrastructure, dynamics, and physiology, and highlight notable discoveries they enabled.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Dinâmica Mitocondrial
/
Mitocôndrias
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article