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Key Issues of Economic Evaluations for Health Technology Assessment in China: A Nationwide Expert Survey.
Liu, Gordon G; Guan, Haijing; Peng, Nan; Xie, Shitong; Wang, Kang; Liu, Larry Z; Zhou, Yanbing; Jin, Huajie.
Afiliação
  • Liu GG; Institute for Global Health and Development, Peking University, Beijing, China; National School of Development, Peking University, Beijing, China.
  • Guan H; China Center for Health Economic Research, Peking University, Beijing, China; Department of Pharmacy, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
  • Peng N; China Center for Health Economic Research, Peking University, Beijing, China; School of International Pharmaceutical Business, China Pharmaceutical University, Jiangsu Province, Nanjing City, China.
  • Xie S; School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, China.
  • Wang K; King's Health Economics, Institute of Psychiatry, Psychology & Neuroscience at King's College London, London, England, UK.
  • Liu LZ; Center for Observational and Real-world Evidence, Merck & Co, Inc, Rahway, NJ, USA; Weill Cornell Medical College, New York, NY, USA.
  • Zhou Y; Center for Observational and Real-world Evidence, Merck & Co, Inc, Rahway, NJ, USA.
  • Jin H; Institute for Global Health and Development, Peking University, Beijing, China; King's Health Economics, Institute of Psychiatry, Psychology & Neuroscience at King's College London, London, England, UK. Electronic address: huajie.jin@kcl.ac.uk.
Value Health ; 2024 Jul 06.
Article em En | MEDLINE | ID: mdl-38977183
ABSTRACT

OBJECTIVES:

Health technology assessment (HTA) is increasingly crucial in medicine price negotiations in China, yet previous appraisals revealed national discrepancies on key economic evaluation issues willingness-to-pay threshold, pricing models for multi-indication medicines, and comparator selection principles. This study aimed to collect expert opinions on these issues for future HTA evaluations.

METHODS:

A nationwide anonymous web-based survey encompassing experts across academia, HTA, consultancy/contract research organization/industry, service provider, and payer. In 2023, a generic invitation containing a web link to the questionnaire was disseminated via WeChat using convenience and snowball sampling. Agreement rates for questionnaire views were analyzed using descriptive statistics. The relationship between participants' responses and demographics was examined using appropriate logistic models.

RESULTS:

A total of 303 responses were received from experts in 34 cities. Key expert views include a suggested base willingness-to-pay threshold ranging from 0.5 to 1.5 times gross domestic product (52.1% agreement); elevated thresholds for childhood diseases, rare diseases, end-of-life diseases, and first-in-class medicines (>78.0% agreement); a single pricing model for multi-indication medicines (60.4% agreement); consideration of multiple medicines as comparators (79.9% agreement); and avoiding the use of centrally procured medicines as comparators for medicines with a time to market of less than 3 years (71.0% agreement). Participants who are service provider had lower odds of selecting higher thresholds (odds ratio 0.26; P < .01) than responders from consultancy/contract research organization/industry.

CONCLUSIONS:

Expert views indicate the need for substantial changes in China's current HTA methods, highlighting the need for increased investment in HTA processes and expertise cultivation.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article