Biliary atresia and cholestasis plasma non-targeted metabolomics unravels perturbed metabolic pathways and unveils a diagnostic model for biliary atresia.

Du, Bang; Mu, Kai; Sun, Meng; Yu, Zhidan; Li, Lifeng; Hou, Ligong; Wang, Qionglin; Sun, Jushan; Chen, Jinhua; Zhang, Xianwei; Zhang, Wancun

Du, Bang; Mu, Kai; Sun, Meng; Yu, Zhidan; Li, Lifeng; Hou, Ligong; Wang, Qionglin; Sun, Jushan; Chen, Jinhua; Zhang, Xianwei; Zhang, Wancun.

Afiliação

Du B; Health Commission of Henan Province Key Laboratory for Precision Diagnosis and Treatment of Pediatric Tumor, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, 450018, China.
Mu K; Henan Key Laboratory of Rare Diseases, Endocrinology and Metabolism Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, 471003, China.
Sun M; Henan Key Laboratory of Children's Genetics and Metabolic Diseases, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, 450018, China.
Yu Z; Health Commission of Henan Province Key Laboratory for Precision Diagnosis and Treatment of Pediatric Tumor, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, 450018, China.
Li L; Health Commission of Henan Province Key Laboratory for Precision Diagnosis and Treatment of Pediatric Tumor, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, 450018, China.
Hou L; Henan International Joint Laboratory for Prevention and Treatment of Pediatric Disease, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, 450018, China.
Wang Q; Henan Key Laboratory of Children's Genetics and Metabolic Diseases, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, 450018, China.
Sun J; Health Commission of Henan Province Key Laboratory for Precision Diagnosis and Treatment of Pediatric Tumor, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, 450018, China. zzetyysjs@163.com.
Chen J; Department of Pharmacy, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, 450008, China. cjh070310216@163.com.
Zhang X; Health Commission of Henan Province Key Laboratory for Precision Diagnosis and Treatment of Pediatric Tumor, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, 450018, China. zhangxw956658@126.com.
Zhang W; Henan Key Laboratory of Rare Diseases, Endocrinology and Metabolism Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, 471003, China. zhangxw956658@126.com.

Sci Rep ; 14(1): 15796, 2024 07 09.

Article em En | MEDLINE | ID: mdl-38982277

Assuntos

Atresia Biliar; Biomarcadores; Colestase; Redes e Vias Metabólicas; Metabolômica; Atresia Biliar/sangue; Atresia Biliar/diagnóstico; Atresia Biliar/metabolismo; Humanos; Metabolômica/métodos; Colestase/sangue; Colestase/diagnóstico; Colestase/metabolismo; Feminino; Masculino; Biomarcadores/sangue; Lactente; Pré-Escolar; Diagnóstico Diferencial; Curva ROC; Metaboloma; Estudos de Casos e Controles; Criança

Palavras-chave

Biliary atresia; Blood plasma; Cholestasis; Diagnostic model; Metabolomics

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Atresia Biliar / Biomarcadores / Colestase / Redes e Vias Metabólicas / Metabolômica Limite: Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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