ECM Microenvironment in Vascular Homeostasis: New Targets for Atherosclerosis.
Physiology (Bethesda)
; 39(5): 0, 2024 Sep 01.
Article
em En
| MEDLINE
| ID: mdl-38984789
ABSTRACT
Alterations in vascular extracellular matrix (ECM) components, interactions, and mechanical properties influence both the formation and stability of atherosclerotic plaques. This review discusses the contribution of the ECM microenvironment in vascular homeostasis and remodeling in atherosclerosis, highlighting Cartilage oligomeric matrix protein (COMP) and its degrading enzyme ADAMTS7 as examples, and proposes potential avenues for future research aimed at identifying novel therapeutic targets for atherosclerosis based on the ECM microenvironment.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Aterosclerose
/
Matriz Extracelular
/
Homeostase
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article