Your browser doesn't support javascript.
loading
Residential exposure to ambient fine particulate matter (PM2.5) and nitrogen dioxide (NO2) and incident breast cancer among young women in Ontario, Canada.
Le Provost, Blandine; Parent, Marie-Élise; Villeneuve, Paul J; Waddingham, Claudia M; Brook, Jeffrey R; Lavigne, Eric; Dugandzic, Rose; Harris, Shelley A.
Afiliação
  • Le Provost B; Department of Neuroscience, Carleton University, Ottawa, Ontario, Canada; Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED), École de Santé Publique, Université de Bordeaux, Bordeaux, France.
  • Parent MÉ; Epidemiology and Biostatistics Unit, Centre Armand-Frappier Santé Biotechnologie, Institut national de la recherche scientifique, Université du Québec, Laval, Québec, Canada; Department of Social and Preventive Medicine, School of Public Health, Université de Montréal, Montreal, Quebec, Canada; Cent
  • Villeneuve PJ; Department of Neuroscience, Carleton University, Ottawa, Ontario, Canada. Electronic address: Paul.Villeneuve@carleton.ca.
  • Waddingham CM; Department of Neuroscience, Carleton University, Ottawa, Ontario, Canada.
  • Brook JR; Divisions of Epidemiology and Occupational and Environmental Health, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada; Department of Civil and Mineral Engineering, University of Toronto, Toronto, Ontario, Canada.
  • Lavigne E; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada; Population Studies Division, Health Canada, Ottawa, Ontario, Canada.
  • Dugandzic R; Office of Environmental Health, Health Canada, Ottawa, Ontario, Canada.
  • Harris SA; Divisions of Epidemiology and Occupational and Environmental Health, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
Cancer Epidemiol ; 92: 102606, 2024 Jul 09.
Article em En | MEDLINE | ID: mdl-38986354
ABSTRACT

BACKGROUND:

Air pollution has been classified as a human carcinogen based largely on findings for respiratory cancers. Emerging, but limited, evidence suggests that it increases the risk of breast cancer, particularly among younger women. We characterized associations between residential exposure to ambient fine particulate matter (PM2.5) and nitrogen dioxide (NO2) and breast cancer. Analyses were performed using data collected in the Ontario Environmental Health Study (OEHS).

METHODS:

The OEHS, a population-based case-control study, identified incident cases of breast cancer in Ontario, Canada among women aged 18-45 between 2013 and 2015. A total of 465 pathologically confirmed primary breast cancer cases were identified from the Ontario Cancer Registry, while 242 population-based controls were recruited using random-digit dialing. Self-reported questionnaires were used to collect risk factor data and residential histories. Land-use regression and remote-sensing estimates of NO2 and PM2.5, respectively, were assigned to the residential addresses at interview, five years earlier, and at menarche. Logistic regression was used to estimate odds ratios (OR) and their 95 % confidence intervals (CI) in relation to an interquartile range (IQR) increase in air pollution, adjusting for possible confounders.

RESULTS:

PM2.5 and NO2 were positively correlated with each other (r = 0.57). An IQR increase of PM2.5 (1.9 µg/m3) and NO2 (6.6 ppb) at interview residence were associated with higher odds of breast cancer and the adjusted ORs and 95 % CIs were 1.37 (95 % CI = 0.98-1.91) and 2.33 (95 % CI = 1.53-3.53), respectively. An increased odds of breast cancer was observed with an IQR increase in NO2 at residence five years earlier (OR = 2.16, 95 % CI 1.41-3.31), while no association was observed with PM2.5 (OR = 0.96, 95 % CI 0.64-1.42).

CONCLUSIONS:

Our findings support the hypothesis that exposure to ambient air pollution, especially those from traffic sources (i.e., NO2), increases the risk of breast cancer in young women.
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article