Scavengers in islets fuel diabetic autoimmunity.
Immunity
; 57(7): 1448-1451, 2024 Jul 09.
Article
em En
| MEDLINE
| ID: mdl-38986438
ABSTRACT
Autoreactive lymphocytes that infiltrate the pancreatic islet environment and target ß cells are primary drivers of type 1 diabetes. In this issue of Immunity, Srivastava et al.1 examine the role of the islet microenvironment in autoimmunity and find that the scavenging receptor CXCL16 on islet-resident macrophages uptakes oxidized low-density lipoproteins and promotes the differentiation and survival of infiltrating pathogenic CD8+ T cells.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Autoimunidade
/
Ilhotas Pancreáticas
/
Linfócitos T CD8-Positivos
/
Diabetes Mellitus Tipo 1
/
Macrófagos
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article