An optimized cyclophosphamide-treated mouse model of Mycobacterium abscessus pulmonary infection.
Antimicrob Agents Chemother
; 68(8): e0152023, 2024 Aug 07.
Article
em En
| MEDLINE
| ID: mdl-38990014
ABSTRACT
Mycobacterium abscessus pulmonary infections are increasingly problematic, especially for immunocompromised individuals and those with underlying lung conditions. Currently, there is no reliable standardized treatment, underscoring the need for improved preclinical drug testing. We present a simplified immunosuppressed mouse model using only four injections of cyclophosphamide, which allows for sustained M. abscessus lung burden for up to 16 days. This model proved effective for antibiotic efficacy evaluation, as demonstrated with imipenem or amikacin.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Amicacina
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Ciclofosfamida
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Modelos Animais de Doenças
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Mycobacterium abscessus
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Antibacterianos
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Infecções por Mycobacterium não Tuberculosas
Limite:
Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article