Three-component cascade carbopalladation/Heck cyclization/borylation: facile access to boryl-functionalized indenes.
Chem Commun (Camb)
; 60(62): 8075-8078, 2024 Jul 30.
Article
em En
| MEDLINE
| ID: mdl-38990065
ABSTRACT
A mild Pd-catalyzed three-component cascade cyclization functionalization of o-iodostyrenes, internal alkynes and boron reagents is presented. The transformation is driven by a controlled reaction sequence of intermolecular carbopalladation, intramolecular Heck-type cyclization, and a borylation process to give versatile boryl-functionalized indene skeletons in a selective fashion. Significantly, (Bpin)2, (Bneop)2 and CH2(Bpin)2 as boron sources are all tolerated. Additionally, the synthetic utility of this approach is demonstrated by gram-scale synthesis and synthetic transformations.
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MEDLINE
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En
Ano de publicação:
2024
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Article