Breathe and bloom: Gut hypoxia limits C. albicans growth.

Mishra, Animesh A; Koh, Andrew Y

Mishra, Animesh A; Koh, Andrew Y.

Afiliação

Mishra AA; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Koh AY; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Harold C. Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: andrew.koh@utsouthwestern.edu.

Cell Host Microbe ; 32(7): 1041-1043, 2024 Jul 10.

Article em En | MEDLINE | ID: mdl-38991499

ABSTRACT

ABSTRACT

Multiple host and microbial factors dictate whether Candida albicans can colonize the mammalian gastrointestinal tract. In this issue of Cell Host & Microbe, Savage et al. demonstrate that restoration of intestinal epithelial hypoxia is sufficient to restore Candida albicans colonization resistance, even when other Candida inhibitory effectors remain depleted.

Assuntos

Candida albicans; Candidíase; Trato Gastrointestinal; Candida albicans/crescimento & desenvolvimento; Candida albicans/fisiologia; Humanos; Trato Gastrointestinal/microbiologia; Candidíase/microbiologia; Animais; Hipóxia/metabolismo; Mucosa Intestinal/microbiologia; Mucosa Intestinal/metabolismo; Camundongos; Interações Hospedeiro-Patógeno; Microbioma Gastrointestinal/fisiologia

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Candida albicans / Candidíase / Trato Gastrointestinal Limite: Animals / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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