R1205H (Vicenza) causes conformational changes in the von Willebrand factor D'D3 domains and enhances von Willebrand factor binding to clearance receptors LRP1 and SR-AI.

Atiq, Ferdows; Rawley, Orla; O'Sullivan, Jamie M; Özbil, Mehmet; Doherty, Dearbhla; Cooke, Niamh; Terraube, Virginie; Chion, Alain; Amin, Aamir; Hulshof, Anne-Marije; Baci, Bogdan; Byrne, Ciara; Aburawi, Hanan E; Lillicrap, David; O'Donnell, James S

Atiq, Ferdows; Rawley, Orla; O'Sullivan, Jamie M; Özbil, Mehmet; Doherty, Dearbhla; Cooke, Niamh; Terraube, Virginie; Chion, Alain; Amin, Aamir; Hulshof, Anne-Marije; Baci, Bogdan; Byrne, Ciara; Aburawi, Hanan E; Lillicrap, David; O'Donnell, James S.

Afiliação

Atiq F; Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.
Rawley O; Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada.
O'Sullivan JM; Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.
Özbil M; Computational Biochemistry Group, Gebze Technical University, Institute of Biotechnology, Gebze, Kocaeli, Turkey.
Doherty D; Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.
Cooke N; BioMedicine Design, Pfizer, Grange Castle, Dublin, Ireland.
Terraube V; BioMedicine Design, Pfizer, Grange Castle, Dublin, Ireland.
Chion A; Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.
Amin A; Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.
Hulshof AM; Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.
Baci B; Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.
Byrne C; Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.
Aburawi HE; Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.
Lillicrap D; Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada.
O'Donnell JS; Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland; National Coagulation Centre, St James's Hospital, Dublin, Ireland. Electronic address: jamesodonnell@rcsi.ie.