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Risk of Cardiovascular Events in Metabolically Healthy Overweight or Obese Adults: Role of LDL-Cholesterol in the Stratification of Risk.
Palatini, Paolo; Virdis, Agostino; Masi, Stefano; Mengozzi, Alessandro; Casiglia, Edoardo; Tikhonoff, Valerie; Cicero, Arrigo F G; Ungar, Andrea; Parati, Gianfranco; Rivasi, Giulia; Salvetti, Massimo; Barbagallo, Carlo Maria; Bombelli, Michele; Dell'Oro, Raffaella; Bruno, Berardino; Lippa, Luciano; D'Elia, Lanfranco; Masulli, Maria; Verdecchia, Paolo; Reboldi, Gianpaolo; Angeli, Fabio; Cianci, Rosario; Mallamaci, Francesca; Cirillo, Massimo; Rattazzi, Marcello; Cirillo, Pietro; Gesualdo, Loreto; Russo, Elisa; Mazza, Alberto; Giannattasio, Cristina; Maloberti, Alessandro; Volpe, Massimo; Tocci, Giuliano; Iaccarino, Guido; Nazzaro, Pietro; Galletti, Ferruccio; Ferri, Claudio; Desideri, Giovambattista; Viazzi, Francesca; Pontremoli, Roberto; Muiesan, Maria Lorenza; Grassi, Guido; Borghi, Claudio.
Afiliação
  • Palatini P; Department of Medicine, Studium Patavinum, University of Padova, 35128 Padua, Italy.
  • Virdis A; Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.
  • Masi S; Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.
  • Mengozzi A; Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.
  • Casiglia E; Department of Medicine, Studium Patavinum, University of Padova, 35128 Padua, Italy.
  • Tikhonoff V; Department of Medicine, University of Padova, 35128 Padua, Italy.
  • Cicero AFG; Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy.
  • Ungar A; Department of Geriatric and Intensive Care Medicine, Careggi Hospital, University of Florence, 50121 Florence, Italy.
  • Parati G; Istituto Auxologico Italiano, S. Luca Hospital, University of Milan-Bicocca, 20126 Milan, Italy.
  • Rivasi G; Department of Medicine and Surgery, University of Milano-Bicocca, Piazza dell'Ateneo Nuovo, 20126 Milan, Italy.
  • Salvetti M; Department of Geriatric and Intensive Care Medicine, Careggi Hospital, University of Florence, 50121 Florence, Italy.
  • Barbagallo CM; Department of Clinical and Experimental Sciences, University of Brescia, 25123 Brescia, Italy.
  • Bombelli M; Biomedical Department of Internal Medicine and Specialistics, University of Palermo, 90100 Palermo, Italy.
  • Dell'Oro R; Department of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.
  • Bruno B; Department of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.
  • Lippa L; Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
  • D'Elia L; Italian Society of General Medicine (SIMG), 67051 Avezzano, Italy.
  • Masulli M; Department of Clinical Medicine and Surgery, Medical School, "Federico II" University of Naples, 80133 Naples, Italy.
  • Verdecchia P; Department of Clinical Medicine and Surgery, Medical School, "Federico II" University of Naples, 80133 Naples, Italy.
  • Reboldi G; Hospital S. Maria della Misericordia, 06100 Perugia, Italy.
  • Angeli F; Department of Medical and Surgical Science, University of Perugia, 06100 Perugia, Italy.
  • Cianci R; Department of Medicine and Surgery, University of Insubria, 21100 Varese, Italy.
  • Mallamaci F; Department of Medicine and Cardiopulmonary Rehabilitation, Maugeri Care and Research Institutes, IRCCS, 21100 Varese, Italy.
  • Cirillo M; Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy.
  • Rattazzi M; CNR-IFC, Clinical Epidemiology of Renal Diseases and Hypertension, Reggio Cal Unit, 89124 Reggio Calabria, Italy.
  • Cirillo P; Department of Public Health, "Federico II" University of Naples, 80133 Naples, Italy.
  • Gesualdo L; Department of Medicine, University of Padova, 35128 Padua, Italy.
  • Russo E; Medicina Interna 1°, Ca' Foncello University Hospital, 31100 Treviso, Italy.
  • Mazza A; Nephrology, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation, "Aldo Moro" University of Bari, 70122 Bari, Italy.
  • Giannattasio C; Nephrology, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation, "Aldo Moro" University of Bari, 70122 Bari, Italy.
  • Maloberti A; Department of Internal Medicine, University of Genoa, Policlinico San Martino, 16132 Genova, Italy.
  • Volpe M; Department of Internal Medicine, Hypertension Unit, General Hospital, 45100 Rovigo, Italy.
  • Tocci G; Cardiology IV, 'A. De Gasperis' Department, Niguarda Ca' Granda Hospital, 20162 Milano, Italy.
  • Iaccarino G; Cardiology IV, 'A. De Gasperis' Department, Niguarda Ca' Granda Hospital, 20162 Milano, Italy.
  • Nazzaro P; Department of Clinical and Molecular Medicine, University of Rome Sapienza, 00161 Rome, Italy.
  • Galletti F; IRCCS San Raffaele, 00161 Rome, Italy.
  • Ferri C; Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, University of Rome Sapienza, Sant'Andrea Hospital, 00185 Rome, Italy.
  • Desideri G; Department of Advanced Biomedical Sciences, "Federico II" University of Naples, 80133 Naples, Italy.
  • Viazzi F; Department of Medical Basic Sciences, Neurosciences and Sense Organs, Medical School, University of Bari, 70122 Bari, Italy.
  • Pontremoli R; Department of Clinical Medicine and Surgery, Medical School, "Federico II" University of Naples, 80133 Naples, Italy.
  • Muiesan ML; Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
  • Grassi G; Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
  • Borghi C; Department of Internal Medicine, University of Genoa, Policlinico San Martino, 16132 Genova, Italy.
Diagnostics (Basel) ; 14(13)2024 Jun 21.
Article em En | MEDLINE | ID: mdl-39001205
ABSTRACT
The objective of this study was to investigate the longitudinal association of metabolically healthy overweight/obese adults with major adverse cardiovascular events (MACE) and the effect of LDL-cholesterol levels on this association. This study was conducted with 15,904 participants from the URRAH study grouped according to BMI and metabolic status. Healthy metabolic status was identified with and without including LDL-cholesterol. The risk of MACE during 11.8 years of follow-up was evaluated with multivariable Cox regressions. Among the participants aged <70 years, high BMI was associated with an increased risk of MACE, whereas among the older subjects it was associated with lower risk. Compared to the group with normal weight/healthy metabolic status, the metabolically healthy participants aged <70 years who were overweight/obese had an increased risk of MACE with an adjusted hazard ratio of 3.81 (95% CI, 1.34-10.85, p = 0.012). However, when LDL-cholesterol < 130 mg/dL was included in the definition of healthy metabolic status, no increase in risk was found in the overweight/obese adults compared to the normal weight individuals (hazard ratio 0.70 (0.07-6.71, p = 0.75). The present data show that the risk of MACE is increased in metabolically healthy overweight/obese individuals identified according to standard criteria. However, when LDL-cholesterol is included in the definition, metabolically healthy individuals who are overweight/obese have no increase in risk.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article