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Association Between Serum Levels of Anti-heat Shock Protein 27 Antibody and Liver Cell Injury in Chronic Hepatitis B.
Yousefli, Zahra; Meshkat, Zahra; Ghayour-Mobarhan, Majid; Hosseini, Seyed Mousalreza; Tavallaie, Shima; Kazemianfar, Ehsan; Soltanian, Hossein; Aminzadeh, Afarin; Ghasemi, Amirhosein; Kashmari, Maryam; Nasiraee, Mohammadreza; Meshkat, Mojtaba; Jarrahi, Lida; Gholoobi, Aida.
Afiliação
  • Yousefli Z; Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Meshkat Z; Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Ghayour-Mobarhan M; Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Hosseini SM; Department of Gastroenterology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Tavallaie S; Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Kazemianfar E; Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Soltanian H; Student Research Committee, Faculty of Paramedical Science, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Aminzadeh A; Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran.
  • Ghasemi A; Student Research Committee, Faculty of Paramedical Science, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Kashmari M; Blood Borne Infections Research Center, Academic Center for Education, Culture & Research (ACECR), Razavi Khorasan Branch, Mashhad, Iran.
  • Nasiraee M; Student Research Committee, Faculty of Paramedical Science, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Meshkat M; Student Research Committee, Faculty of Paramedical Science, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Jarrahi L; Student Research Committee, Faculty of Paramedical Science, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Gholoobi A; Student Research Committee, Faculty of Paramedical Science, Mashhad University of Medical Sciences, Mashhad, Iran.
Indian J Clin Biochem ; 39(3): 365-372, 2024 Jul.
Article em En | MEDLINE | ID: mdl-39005869
ABSTRACT
Heat Shock Protein 27 (HSP27), an anti-HBV factor, exists in the intracellular and extracellular spaces. As an inflammatory modulator, serum HSP27 (sHSP27) is associated with elevated pro-inflammatory cytokines and a higher likelihood of hepatocellular carcinoma in chronic hepatitis. SHSP27 results in natural antibody production (anti-HSP27-Ab) that is more stable and easily detectable compared to sHSP27. We aimed to investigate any potential association between anti-HSP27-Ab level and chronic hepatitis B (CHB) progression and inflammation indicated by liver cell injury and HBV replication. This cross-sectional study was conducted on 91 patients with CHB and 92 individuals without CHB. Following demographic data collection, anti-HSP27-Ab, serum lipids including total cholesterol, triglyceride, LDL-C, HDL-C, and aminotransferase levels were measured using enzymatic assays in participants' serum samples. HBV DNA was also measured by quantitative PCR in CHB patients. Bivariate and multivariate analyses showed a significantly higher mean level of anti-HSP27-Ab in CHB than in healthy individuals (0.304 vs. 0.256AU/ml, P value = 0.015). These levels held significant differences in the CHB subgroups of male patients, at the age of 50 years and above, with non-smoking status, elevated aminotransferase levels, and hypotriglyceridemia (P value < 0.05). However, no difference was found between the antibody levels and HBV DNA copies (P value > 0.05). This study provides evidence that anti-HSP27 antibody levels can reflect the degree of liver necrosis indicated by aminotransferase levels. Regarding the higher incidence rate of HBV-associated complications in 50 to 60-year-old men, monitoring the antibody can be beneficial in managing this group of CHB patients, which deserves further investigation.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article