Pain after oocyte retrieval in women with endometriosis undergoing fertility preservation or IVF.
Reprod Biomed Online
; 49(3): 104100, 2024 May 03.
Article
em En
| MEDLINE
| ID: mdl-39008944
ABSTRACT
RESEARCH QUESTION Do women with endometriosis undergoing oocyte retrieval for fertility preservation experience the same level of pain as women undergoing oocyte retrieval for IVF? DESIGN:
This retrospective cohort study included 796 cycles in women with endometriosis undergoing oocyte retrieval for fertility preservation (nâ¯=â¯401) or IVF (nâ¯=â¯395) between January 2020 and October 2022. Post-operative pain assessments were compared between the two groups using a numeric rating scale (NRS).RESULTS:
Women in the fertility preservation group were younger (32.1 ± 4.2 years versus 35.1 ± 4.1 years; P < 0.001), had a lower body mass index (22.8 ± 3.9 kg/m2 versus 24.6 ± 4.4 kg/m2; P < 0.001) and had a lower concentration of anti-Müllerian hormone (1.8 ± 1.5 ng/ml versus 2.15 ± 2.11 ng/ml; Pâ¯=â¯0.026) in comparison with women in the IVF group. The oestrogen concentration on the day of ovulation trigger was higher in women in the fertility preservation group (2188 ± 1152 pg/ml versus 2081 ± 995 pg/ml; Pâ¯=â¯0.004), and the prevalence rates of adenomyosis and digestive endometrial lesions were lower in women in the fertility preservation group (14% versus 29%, P < 0.001; 16% versus 25%, Pâ¯=â¯0.003, respectively) compared with women in the IVF group. After oocyte puncture, more women in the fertility preservation group had an NRS pain score >3 (moderate to severe pain) compared with women in the IVF group (20% versus 14%; Pâ¯=â¯0.018). The progestin-primed ovarian stimulation (PPOS) protocol was identified as an independent predictive factor of greater post-operative pain (adjusted OR 2.30, 95% CI 1.06-5.15; Pâ¯=â¯0.039).CONCLUSION:
Women with endometriosis undergoing fertility preservation reported more intense post-operative pain in the recovery room than women undergoing IVF. The PPOS protocol was an independent risk factor of intense pain (NRS pain score >3) in women with endometriosis, but further studies are needed to confirm this result.
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Base de dados:
MEDLINE
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En
Ano de publicação:
2024
Tipo de documento:
Article