Divergent evolution of male-determining loci on proto-Y chromosomes of the housefly.
Nat Commun
; 15(1): 5984, 2024 Jul 16.
Article
em En
| MEDLINE
| ID: mdl-39013946
ABSTRACT
Houseflies provide a good experimental model to study the initial evolutionary stages of a primary sex-determining locus because they possess different recently evolved proto-Y chromosomes that contain male-determining loci (M) with the same male-determining gene, Mdmd. We investigate M-loci genomically and cytogenetically revealing distinct molecular architectures among M-loci. M on chromosome V (MV) has two intact Mdmd copies in a palindrome. M on chromosome III (MIII) has tandem duplications containing 88 Mdmd copies (only one intact) and various repeats, including repeats that are XY-prevalent. M on chromosome II (MII) and the Y (MY) share MIII-like architecture, but with fewer repeats. MY additionally shares MV-specific sequence arrangements. Based on these data and karyograms using two probes, one derives from MIII and one Mdmd-specific, we infer evolutionary histories of polymorphic M-loci, which have arisen from unique translocations of Mdmd, embedded in larger DNA fragments, and diverged independently into regions of varying complexity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Evolução Molecular
/
Moscas Domésticas
Limite:
Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article