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Pseudomonas aeruginosa in chronic lung disease: untangling the dysregulated host immune response.
Nickerson, Rhea; Thornton, Christina S; Johnston, Brent; Lee, Amy H Y; Cheng, Zhenyu.
Afiliação
  • Nickerson R; Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada.
  • Thornton CS; Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
  • Johnston B; Department of Microbiology, Immunology and Infectious Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
  • Lee AHY; Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada.
  • Cheng Z; Department of Molecular Biology and Biochemistry, Faculty of Science, Simon Fraser University, Burnaby, BC, Canada.
Front Immunol ; 15: 1405376, 2024.
Article em En | MEDLINE | ID: mdl-39015565
ABSTRACT
Pseudomonas aeruginosa is a highly adaptable opportunistic pathogen capable of exploiting barriers and immune defects to cause chronic lung infections in conditions such as cystic fibrosis. In these contexts, host immune responses are ineffective at clearing persistent bacterial infection, instead driving a cycle of inflammatory lung damage. This review outlines key components of the host immune response to chronic P. aeruginosa infection within the lung, beginning with initial pathogen recognition, followed by a robust yet maladaptive innate immune response, and an ineffective adaptive immune response that propagates lung damage while permitting bacterial persistence. Untangling the interplay between host immunity and chronic P. aeruginosa infection will allow for the development and refinement of strategies to modulate immune-associated lung damage and potentiate the immune system to combat chronic infection more effectively.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pseudomonas aeruginosa / Infecções por Pseudomonas / Interações Hospedeiro-Patógeno / Imunidade Inata Limite: Animals / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pseudomonas aeruginosa / Infecções por Pseudomonas / Interações Hospedeiro-Patógeno / Imunidade Inata Limite: Animals / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article