Brazil Nut (Bertholletia excelsa H.B.K.) Consumption in Energy-Restricted Intervention Decreases Proinflammatory Markers and Intestinal Permeability of Women with Overweight/Obesity: A Controlled Trial (Brazilian Nuts Study).
J Nutr
; 154(9): 2670-2679, 2024 Sep.
Article
em En
| MEDLINE
| ID: mdl-39025334
ABSTRACT
BACKGROUND:
Obesity is associated with low-grade inflammation and increased intestinal permeability (IP). The Brazil nut (BN) (Bertholletia excelsa H.B.K.) appears to be a promising dietary intervention to control inflammation by enhancing antioxidant defenses.OBJECTIVES:
We aimed to assess the effect of daily BN consumption on inflammatory biomarkers and IP in the context of an energy-restricted intervention. Furthermore, we evaluated the correlation between the changes in these inflammatory markers and the changes in serum selenium and IP.METHODS:
In this 8-wk nonrandomized controlled trial, 56 women with overweight or obesity were allocated into 2 groups, both following an energy-restricted diet (-500 kcal/d). The control group (CO) consumed a nut-free diet, while the BN group consumed 8 g BN/d, providing 347.2 µg selenium (Se). Inflammatory cytokines were analyzed in plasma and Se in serum. IP was assessed using the lactulose/mannitol test (LM ratio).RESULTS:
Forty-six women completed the intervention. Both groups achieved similar energy restriction (CO Δ= -253.7 ± 169.4 kcal/d; BN Δ= -265.8 ± 141.8 kcal/d) and weight loss (CO Δ= -2.5 ± 0.5 kg; BN Δ= -3.5 ± 0.5 kg). The BN group showed lower values of C-reactive protein, tumor necrosis factor, interleukin (IL)1-ß, IL-8, percentage lactulose excretion, and LM ratio than the CO group. Additionally, changes in serum Se concentration were predictive of changes in IL-8 concentration (ß -0.054; adjusted R2 0.100; 95% confidence interval [CI] -0.100; -0.007; P = 0.025), and changes in IL-8 were predictive of changes in the LM ratio (ß 0.006; adjusted R2 0.101; 95% CI 0.001, 0.011; P = 0.024).CONCLUSIONS:
Regular intake of BNs can be a promising complementary dietary strategy for controlling low-grade inflammation and improving IP in women with overweight/obesity undergoing energy-restricted treatment. However, the effects of BNs seem to be Se status-dependent. This trial was registered at the Brazilian Registry of Clinical Trials (ReBEC https//ensaiosclinicos.gov.br/rg/RBR-3ntxrm/.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Selênio
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Biomarcadores
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Bertholletia
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Sobrepeso
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Obesidade
Limite:
Adult
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Female
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Humans
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Middle aged
País como assunto:
America do sul
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Brasil
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article