Investigating the Expression Levels of Bax and Bcl-2 Genes in Peripheral Blood Lymphocytes of Industrial Radiation Workers in the Asaluyeh Region.
J Biomed Phys Eng
; 14(3): 275-286, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-39027712
ABSTRACT
Background:
Industrial radiography uses gamma or X-ray radionuclide sources to investigate the safety of industrial materials. Industrial radiation workers receive the highest occupational radiation doses.Objective:
The present study investigates the relationship between Bax and Bcl-2 gene expression variables in industrial radiation workers. Material andMethods:
In this case-control study, data was collected using blood sampling from 40 workers, including two groups of non-radiation and radiation workers employed at the location. Expression levels of Bax and Bcl-2 genes were assessed in the laboratory. The environmental and absorbed doses of workers were measured using environmental and pen dosimeters.Results:
Statistical analysis showed that the radiation group's Bcl-2 gene expression level was significantly higher. Findings also demonstrated a correlation between Bcl-2 gene expression and the number of workdays. Also, the Bax gene expression did not show a significant change, and the expression ratio of Bax/Bcl-2 was insignificant in the two groups.Conclusion:
Exposure to low doses of radiation could promote an adaptive response in cells by increasing Bcl-2 gene expression.
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Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article