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Deciphering the dynamic code: DNA recognition by transcription factors in the ever-changing genome.
Yao, Yumi Minyi; Miodownik, Irina; O'Hagan, Michael P; Jbara, Muhammad; Afek, Ariel.
Afiliação
  • Yao YM; Department of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot, Israel.
  • Miodownik I; Department of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot, Israel.
  • O'Hagan MP; Department of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot, Israel.
  • Jbara M; School of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv, Israel.
  • Afek A; Department of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot, Israel.
Transcription ; : 1-25, 2024 Jul 20.
Article em En | MEDLINE | ID: mdl-39033307
ABSTRACT
Transcription factors (TFs) intricately navigate the vast genomic landscape to locate and bind specific DNA sequences for the regulation of gene expression programs. These interactions occur within a dynamic cellular environment, where both DNA and TF proteins experience continual chemical and structural perturbations, including epigenetic modifications, DNA damage, mechanical stress, and post-translational modifications (PTMs). While many of these factors impact TF-DNA binding interactions, understanding their effects remains challenging and incomplete. This review explores the existing literature on these dynamic changes and their potential impact on TF-DNA interactions.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article