Your browser doesn't support javascript.
loading
Association between striatal amyloid deposition and motor prognosis in Parkinson's disease.
Park, Mincheol; Kim, Hyun Joo; Baik, Kyoungwon; Na, Han Kyu; Lee, Young-Gun; Yoon, So Hoon; Jeong, Seong Ho; Chung, Seok Jong; Shin, Hae-Won; Lyoo, Chul Hyoung; Sohn, Young H; Lee, Phil Hyu.
Afiliação
  • Park M; Department of Neurology, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Kim HJ; Department of Neurology, Gwangmyeong Hospital, Chung-Ang University College of Medicine, Gwangmyeong, Republic of Korea.
  • Baik K; Department of Nuclear Medicine, Korea University Anam Hospital, Seoul, Republic of Korea.
  • Na HK; Department of Neurology, Korea University Anam Hospital, Seoul, Republic of Korea.
  • Lee YG; Department of Neurology, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Yoon SH; Department of Neurology, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Jeong SH; Department of Neurology, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Republic of Korea.
  • Chung SJ; Department of Neurology, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Shin HW; Department of Neurology, Catholic Kwandong University International St. Mary's Hospital, Incheon, Republic of Korea.
  • Lyoo CH; Department of Neurology, Inje University Sanggye Paik Hospital, Seoul, Republic of Korea.
  • Sohn YH; Department of Neurology, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Lee PH; Department of Neurology, Chung-Ang University College of Medicine, Seoul, Republic of Korea.
Eur J Neurol ; 31(10): e16364, 2024 Oct.
Article em En | MEDLINE | ID: mdl-39034046
ABSTRACT
BACKGROUND AND

PURPOSE:

The co-occurrence of amyloidpathology in Parkinson's disease (PD) is common; however, the role of amyloid-ß deposition in motor prognosis remains elusive. This study aimed to investigate the association between striatal amyloid deposition, motor complications and motor prognosis in patients with PD.

METHODS:

Ninety-six patients with PD who underwent 18F florbetaben (FBB) positron emission tomography were retrospectively assessed. The ratio of the striatum to global (STG) FBB uptake was obtained for each individual, and patients were allotted into low and high STG groups according to the median value. The effect of STG group on regional amyloid deposition, the occurrence of motor complications and longitudinal change in levodopa equivalent dose (LED) requirement were investigated after controlling for age, sex, LED and disease duration at FBB scan.

RESULTS:

The high STG group was associated with lower cortical FBB uptake in the parietal, occipital and posterior cingulate cortices and higher striatal FBB uptake compared to the low STG group. Patients in the high STG group had a higher risk of developing wearing off and levodopa-induced dyskinesia than those in the low STG group, whereas the risk for freezing of gait was comparable between the two groups. The high STG group showed a more rapid increase in LED requirements over time than the low STG group.

CONCLUSIONS:

These findings suggest that relatively high striatal amyloid deposition is associated with poor motor outcomes in patients with PD.
Assuntos
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Corpo Estriado / Tomografia por Emissão de Pósitrons Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Corpo Estriado / Tomografia por Emissão de Pósitrons Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2024 Tipo de documento: Article