Mutational studies with diquat and paraquat in vitro.
Mutat Res
; 68(3): 183-93, 1979 Nov.
Article
em En
| MEDLINE
| ID: mdl-390391
ABSTRACT
Diquat and paraquat were assayed in the following tests. (1) Ames test in Salmonella typhimurium (strains TA1535, TA1537, TA1538, TA98 and TA100) with and without rat-liver microsomal fractions. (2) Resistance to 8-azaguanine in Salmonella typhimurium (strain hisG46, TA92 and TA1535. (3) Repair test in Salmonella typhimurium (strains TA1538 and TA1978). (4) Gene mutations in Aspergillus nidulans 8-AG resistance and methionine suppression (meth A1 locus). (5) Lethal recessive damage in Aspergillus nidulans. (6) Unscheduled DNA synthesis (UDS) in human epithelial-like cells (EUE). Diquat and paraquat were positive in S. typhimurium (in the repair test and the 8-AG resistance system), in A. nidulans (for gene mutations and lethal recessive damage induction) and in EUE cells (UDS induction).
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Base de dados:
MEDLINE
Assunto principal:
Paraquat
/
Compostos de Piridínio
/
Aspergillus nidulans
/
Salmonella typhimurium
/
Microssomos Hepáticos
/
Diquat
/
Mutação
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
1979
Tipo de documento:
Article