The role of galectins in the regulation of autophagy and inflammasome in host immunity.
Semin Immunopathol
; 46(3-4): 6, 2024 Jul 23.
Article
em En
| MEDLINE
| ID: mdl-39042263
ABSTRACT
Galectins, a family of glycan-binding proteins have been shown to bind a wide range of glycans. In the cytoplasm, these glycans can be endogenous (or "self"), originating from damaged endocytic vesicles, or exogenous (or "non-self"), found on the surface of invading microbial pathogens. Galectins can detect these unusual cytosolic exposures to glycans and serve as critical regulators in orchestrating immune responses in innate and adaptive immunity. This review provides an overview of how galectins modulate host cellular responses, such as autophagy, xenophagy, and inflammasome-dependent cell death program, to infection.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Autofagia
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Galectinas
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Inflamassomos
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article