Comparative membrane proteomic analysis of Tritrichomonas foetus isolates.
Sci Rep
; 14(1): 17033, 2024 07 24.
Article
em En
| MEDLINE
| ID: mdl-39043862
ABSTRACT
Tritrichomonas foetus is a flagellated and anaerobic parasite able to infect cattle and felines. Despite its prevalence, there is no effective standardized or legal treatment for T. foetus-infected cattle; the vaccination still has limited success in mitigating infections and reducing abortion risk; and nowadays, the diagnosis of T. foetus presents important limitations in terms of sensitivity and specificity in bovines. Here, we characterize the plasma membrane proteome of T. foetus and identify proteins that are represented in different isolates of this protozoan. Additionally, we performed a bioinformatic analysis that revealed the antigenicity potential of some of those proteins. This analysis is the first study to identify common proteins at the plasma membrane of different T. foetus isolates that could be targets for alternative diagnostic or vaccine techniques in the future.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Protozoários
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Tritrichomonas foetus
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Proteômica
Limite:
Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article