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How c-di-GMP controls progression through the Streptomyces life cycle.
Gallagher, Kelley A; Tschowri, Natalia; Brennan, Richard G; Schumacher, Maria A; Buttner, Mark J.
Afiliação
  • Gallagher KA; Department of Microbiology, Cornell University, Ithaca, New York, USA.
  • Tschowri N; Institute of Microbiology, Leibniz Universität Hannover, 30419 Hannover, Germany.
  • Brennan RG; Department of Biochemistry, Duke University School of Medicine, Durham, NC 27710, USA.
  • Schumacher MA; Department of Biochemistry, Duke University School of Medicine, Durham, NC 27710, USA. Electronic address: maria.schumacher@duke.edu.
  • Buttner MJ; Department of Molecular Microbiology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK. Electronic address: mark.buttner@jic.ac.uk.
Curr Opin Microbiol ; 80: 102516, 2024 Aug.
Article em En | MEDLINE | ID: mdl-39059031
ABSTRACT
Members of the antibiotic-producing bacterial genus Streptomyces undergo a complex developmental life cycle that culminates in the production of spores. Central to control of this cell differentiation process is signaling through the second messenger 3', 5'-cyclic diguanylic acid (c-di-GMP). So far, three proteins that are directly controlled by c-di-GMP in Streptomyces have been functionally and structurally characterized the key developmental regulators BldD and σWhiG, and the glycogen-degrading enzyme GlgX. c-di-GMP signals through BldD and σWhiG, respectively, to control the two most dramatic transitions of the Streptomyces life cycle, the formation of the reproductive aerial hyphae and their differentiation into spore chains. Later in development, c-di-GMP activates GlgX-mediated degradation of glycogen, releasing stored carbon for spore maturation.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Esporos Bacterianos / Streptomyces / Proteínas de Bactérias / Regulação Bacteriana da Expressão Gênica / GMP Cíclico Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Esporos Bacterianos / Streptomyces / Proteínas de Bactérias / Regulação Bacteriana da Expressão Gênica / GMP Cíclico Idioma: En Ano de publicação: 2024 Tipo de documento: Article