Genomic Evolution and Surveillance of Respiratory Syncytial Virus during the 2023-2024 Season.
Viruses
; 16(7)2024 Jul 12.
Article
em En
| MEDLINE
| ID: mdl-39066284
ABSTRACT
Respiratory syncytial virus (RSV) is a significant cause of morbidity, particularly in infants. This study describes RSV genomic diversity and disease outcomes during the 2023-2024 season in the Johns Hopkins Hospital System (JHHS). Between August and December 2023, 406 patient samples were sequenced, showing that RSV-B GB5.0.5a was the dominant genotype detected. RSV-A genotype GA2.3.5 was detected less frequently. Metadata analysis of patient data revealed that, although RSV-B was more commonly detected, patients with RSV-A infections were more frequently hospitalized. Analysis of both the G- and F-genes revealed multiple amino acid substitutions in both RSV-A and RSV-B, with some positions within the F-protein that could be associated with evasion of antibody responses. Phylogenetic analysis revealed the genetic diversity of circulating GB5.0.5a and GA2.3.5 genotypes. This study serves as an important baseline for genomic surveillance of RSV within the JHHS and will assist in characterizing the impact of the newly approved RSV vaccines on RSV genomic evolution and the emergence of escape mutations.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Filogenia
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Estações do Ano
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Variação Genética
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Genoma Viral
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Vírus Sincicial Respiratório Humano
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Infecções por Vírus Respiratório Sincicial
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Evolução Molecular
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Genótipo
Limite:
Adolescent
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Adult
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Aged
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Child
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Child, preschool
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Female
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Humans
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Infant
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article