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Interleukin-6 and interferon-alpha differentially regulate microglia function.
Verdillo, Rovin; Spiteri, Alanna; Viengkhou, Barney; Wishart, Claire; King, Nicholas J C; Hofer, Markus J.
Afiliação
  • Verdillo R; School of Life and Environmental Sciences, The University of Sydney, Sydney, NSW, Australia.
  • Spiteri A; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
  • Viengkhou B; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
  • Wishart C; Viral Immunopathology Laboratory, Infection, Immunity and Inflammation Research Theme, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
  • King NJC; School of Life and Environmental Sciences, The University of Sydney, Sydney, NSW, Australia.
  • Hofer MJ; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
Neuropathol Appl Neurobiol ; 50(4): e13003, 2024 Aug.
Article em En | MEDLINE | ID: mdl-39075830
ABSTRACT
Previous reports have shown that IL-6 and IFN-⍺ induce distinct transcriptomic and morphological changes in microglia. Here, we demonstrate that IL-6 increases tissue surveillance, migration and phagocytosis in primary murine microglia, whereas IFN-⍺ inhibits these functions. Our results provide a crucial link between transcriptome and function. It holds the potential to serve as the foundation for future studies aimed at identifying therapeutic targets for cytokine-mediated neuroinflammatory diseases.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Interleucina-6 / Interferon-alfa / Microglia Limite: Animals Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Interleucina-6 / Interferon-alfa / Microglia Limite: Animals Idioma: En Ano de publicação: 2024 Tipo de documento: Article