The desmosome as a dynamic membrane domain.
Curr Opin Cell Biol
; 90: 102403, 2024 Oct.
Article
em En
| MEDLINE
| ID: mdl-39079221
ABSTRACT
Cell junctions integrate extracellular signals with intracellular responses to polarize tissues, pattern organs, and maintain tissue architecture by promoting cell-cell adhesion and communication. In this review, we explore the mechanisms whereby the adhesive junctions, adherens junctions and desmosomes, co-assemble and then segregate into unique plasma membrane domains. In addition, we highlight emerging evidence that these junctions are spatially and functionally integrated with the endoplasmic reticulum to mediate stress sensing and calcium homeostasis. We conclude with a discussion of the role of the endoplasmic reticulum in the mechanical stress response and how disruption of these connections may cause disease.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Desmossomos
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article