Acute kidney injury is associated with soluble vascular cell adhesion molecule 1 levels and short-term mortality in patients with ischemic stroke.

Jaqueto, Marcel; Alfieri, Daniela Frizon; de Araújo, Maria Caroline Martins; Fürstenberger Lehmann, Ana Lucia Cruz; Flauzino, Tamires; Trevisan, Emmanuelle Roberto; Nagao, Maisa Rocha; de Freitas, Leonardo Bodner; Colado Simão, Andrea Name; Lozovoy, Marcell Alysson Batisti; Delfino, Vinicius Daher Alvares; Reiche, Edna Maria Vissoci

Jaqueto, Marcel; Alfieri, Daniela Frizon; de Araújo, Maria Caroline Martins; Fürstenberger Lehmann, Ana Lucia Cruz; Flauzino, Tamires; Trevisan, Emmanuelle Roberto; Nagao, Maisa Rocha; de Freitas, Leonardo Bodner; Colado Simão, Andrea Name; Lozovoy, Marcell Alysson Batisti; Delfino, Vinicius Daher Alvares; Reiche, Edna Maria Vissoci.

Afiliação

Jaqueto M; Department of Clinical Medicine, Health Science Center and Radiology Service of the University Hospital, State University of Londrina, Paraná, Brazil. Electronic address: mjaqueto@gmail.com.
Alfieri DF; Department of Pharmaceutical Sciences, Health Sciences Center, State University of Londrina, Paraná, Brazil. Electronic address: frizon.alfieri@gmail.com.
de Araújo MCM; Laboratory of Research in Applied Immunology, Health Sciences Center, State University of Londrina, Paraná, Brazil; School of Medicine of Pontifical Catholic University of Paraná, Campus Londrina, Londrina, Paraná, Brazil. Electronic address: mariacarolinearaujo@yahoo.com.br.
Fürstenberger Lehmann ALC; Department of Clinical Medicine, Health Science Center and Radiology Service of the University Hospital, State University of Londrina, Paraná, Brazil. Electronic address: analuciacf@hotmail.com.
Flauzino T; Laboratory of Research in Applied Immunology, Health Sciences Center, State University of Londrina, Paraná, Brazil; School of Medicine of Pontifical Catholic University of Paraná, Campus Londrina, Londrina, Paraná, Brazil. Electronic address: t.flauzino@hotmail.com.
Trevisan ER; Laboratory of Research in Applied Immunology, Health Sciences Center, State University of Londrina, Paraná, Brazil; School of Medicine of Pontifical Catholic University of Paraná, Campus Londrina, Londrina, Paraná, Brazil. Electronic address: mtr3visani@gmail.com.
Nagao MR; Laboratory of Research in Applied Immunology, Health Sciences Center, State University of Londrina, Paraná, Brazil; School of Medicine of Pontifical Catholic University of Paraná, Campus Londrina, Londrina, Paraná, Brazil. Electronic address: maisanagao@gmail.com.
de Freitas LB; Laboratory of Research in Applied Immunology, Health Sciences Center, State University of Londrina, Paraná, Brazil; School of Medicine of Pontifical Catholic University of Paraná, Campus Londrina, Londrina, Paraná, Brazil. Electronic address: leonardo.bodner68@gmail.com.
Colado Simão AN; Laboratory of Research in Applied Immunology, Health Sciences Center, State University of Londrina, Paraná, Brazil; School of Medicine of Pontifical Catholic University of Paraná, Campus Londrina, Londrina, Paraná, Brazil; Department of Pathology, Clinical Analysis, and Toxicology, Health Sciences C
Lozovoy MAB; Laboratory of Research in Applied Immunology, Health Sciences Center, State University of Londrina, Paraná, Brazil; School of Medicine of Pontifical Catholic University of Paraná, Campus Londrina, Londrina, Paraná, Brazil; Department of Pathology, Clinical Analysis, and Toxicology, Health Sciences C
Delfino VDA; Department of Clinical Medicine, Health Science Center and Radiology Service of the University Hospital, State University of Londrina, Paraná, Brazil. Electronic address: vddelfino@sercomtel.com.br.
Reiche EMV; Postgraduate Program of Clinical and Laboratory Pathophysiology, Health Sciences Center, State University of Londrina, Londrina, Paraná, Brazil; Pontificial Catholic University of Paraná, Campus Londrina, School of Medicine, Londrina, Paraná, Brazil. Electronic address: reiche@sercomtel.com.br.

Clin Neurol Neurosurg ; 245: 108470, 2024 Jul 26.

Article em En | MEDLINE | ID: mdl-39079288

ABSTRACT

ABSTRACT

BACKGROUND:

The mechanisms that modulate the onset of acute kidney inlury (AKI) after ischemic stroke (IS) and valuable biomarkers to predict the occurrence and prognosis of AKI among patients with IS are missing.

OBJECTIVE:

To evaluate the frequency of AKI and the prognostic validity of clinical and laboratory biomarkers in predicting AKI and short-term mortality after the IS.

METHODS:

Ninety-five patients with IS were enrolled. Baseline IS severity was assessed using the National Institutes of Health Stroke Scale (NIHSS) and disability was determined after three-month follow-up using the modified Rankin Scale. Patients with IS were also categorized as survivors and non-survivors after the follow-up. Baseline data and laboratory biomarkers were obtained up to 24â¯h of the admission.

RESULTS:

Fifteen (15.7â¯%) patients with IS presented AKI. The proportion of patients with vitamin D deficiency and the mortality were higher among those with AKI than those without AKI (p=0.011 and p-0.009, respectively). Patients with AKI showed higher disability and higher increased soluble vascular cellular adhesion molecule-1 (sVCAM-1) than those without AKI (p=0.029 and p=0.023, respectively). Logistic regression analysis showed that only sVCAM-1 was associated with the occurrence of AKI after IS [odds ratio (OR) 2.715, 95â¯% confidence intereval (CI) 1.12-6.67, p=0.027]. When both AKI and NIHSS were evaluated as explanatory variables, this panel showed an OR of 5.782 (95â¯% CI 1.09-30.43, p<0.001) and correctly classified 83.6â¯% of cases.