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Optimized ultrasound neuromodulation for non-invasive control of behavior and physiology.
Murphy, Keith R; Farrell, Jordan S; Bendig, Jonas; Mitra, Anish; Luff, Charlotte; Stelzer, Ina A; Yamaguchi, Hiroshi; Angelakos, Christopher C; Choi, Mihyun; Bian, Wenjie; DiIanni, Tommaso; Pujol, Esther Martinez; Matosevich, Noa; Airan, Raag; Gaudillière, Brice; Konofagou, Elisa E; Butts-Pauly, Kim; Soltesz, Ivan; de Lecea, Luis.
Afiliação
  • Murphy KR; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
  • Farrell JS; Department of Neurosurgery, Stanford University, Stanford, CA, USA; Department of Neurology, Harvard Medical School, Boston, MA, USA; Rosamund Stone Zander Translational Neuroscience Center, Boston Children's Hospital, Boston, MA, USA; F.M. Kirby Neurobiology Center, Harvard Medical School, Boston,
  • Bendig J; Department of Biomedical Engineering, Columbia University, New York, NY, USA.
  • Mitra A; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
  • Luff C; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
  • Stelzer IA; Department of Anesthesia, Stanford University, Stanford, CA, USA.
  • Yamaguchi H; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA; Department of Neuroscience, Nagoya University, Nagoya, Japan.
  • Angelakos CC; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
  • Choi M; Department of Radiology, Stanford University, Stanford, CA, USA.
  • Bian W; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China; School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.
  • DiIanni T; Department of Radiology, Stanford University, Stanford, CA, USA; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA.
  • Pujol EM; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
  • Matosevich N; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.
  • Airan R; Department of Radiology, Stanford University, Stanford, CA, USA.
  • Gaudillière B; Department of Biomedical Engineering, Columbia University, New York, NY, USA.
  • Konofagou EE; Department of Biomedical Engineering, Columbia University, New York, NY, USA.
  • Butts-Pauly K; Department of Radiology, Stanford University, Stanford, CA, USA.
  • Soltesz I; Department of Neurosurgery, Stanford University, Stanford, CA, USA.
  • de Lecea L; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA. Electronic address: llecea@stanford.edu.
Neuron ; 2024 Jul 29.
Article em En | MEDLINE | ID: mdl-39079529
ABSTRACT
Focused ultrasound can non-invasively modulate neural activity, but whether effective stimulation parameters generalize across brain regions and cell types remains unknown. We used focused ultrasound coupled with fiber photometry to identify optimal neuromodulation parameters for four different arousal centers of the brain in an effort to yield overt changes in behavior. Applying coordinate descent, we found that optimal parameters for excitation or inhibition are highly distinct, the effects of which are generally conserved across brain regions and cell types. Optimized stimulations induced clear, target-specific behavioral effects, whereas non-optimized protocols of equivalent energy resulted in substantially less or no change in behavior. These outcomes were independent of auditory confounds and, contrary to expectation, accompanied by a cyclooxygenase-dependent and prolonged reduction in local blood flow and temperature with brain-region-specific scaling. These findings demonstrate that carefully tuned and targeted ultrasound can exhibit powerful effects on complex behavior and physiology.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article