Neutralizing Autoantibodies against Interleukin-10 in Inflammatory Bowel Disease.
N Engl J Med
; 391(5): 434-441, 2024 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-39083772
ABSTRACT
We discovered high-titer neutralizing autoantibodies against interleukin-10 in a child with infantile-onset inflammatory bowel disease (IBD), a phenocopy of inborn errors of interleukin-10 signaling. After B-cell-depletion therapy and an associated decrease in the anti-interleukin-10 titer, conventional IBD therapy could be withdrawn. A second child with neutralizing anti-interleukin-10 autoantibodies had a milder course of IBD and has been treated without B-cell depletion. We conclude that neutralizing anti-interleukin-10 autoantibodies may be a causative or modifying factor in IBD, with potential implications for therapy. (Funded by the National Institute for Health and Care Research and others.).
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Autoanticorpos
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Doenças Inflamatórias Intestinais
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Interleucina-10
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Anticorpos Neutralizantes
Limite:
Child
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Female
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Humans
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Infant
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Male
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article