Fetal growth restriction and placental defects in obese mice are associated with impaired decidualisation: the role of increased leptin signalling modulators SOCS3 and PTPN2.

Walewska, Edyta; Makowczenko, Karol G; Witek, Krzysztof; Laniecka, Elzbieta; Molcan, Tomasz; Alvarez-Sanchez, Andrea; Kelsey, Gavin; Perez-Garcia, Vicente; Galvão, António M

Walewska, Edyta; Makowczenko, Karol G; Witek, Krzysztof; Laniecka, Elzbieta; Molcan, Tomasz; Alvarez-Sanchez, Andrea; Kelsey, Gavin; Perez-Garcia, Vicente; Galvão, António M.

Afiliação

Walewska E; Department of Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, Olsztyn, Poland.
Makowczenko KG; Department of Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, Olsztyn, Poland.
Witek K; Laboratory of Cell and Tissue Analysis and Imaging, Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, Olsztyn, Poland.
Laniecka E; Department of Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, Olsztyn, Poland.
Molcan T; Department of Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, Olsztyn, Poland.
Alvarez-Sanchez A; Molecular Mechanisms of Placental Invasion, Centro de Investigación Príncipe Felipe, Eduardo Primo Yúfera 3, 46012, Valencia, Spain.
Kelsey G; Epigenetics Programme, The Babraham Institute, Cambridge, CB22 3AT, UK. gavin.kelsey@babraham.ac.uk.
Perez-Garcia V; Centre for Trophoblast Research, University of Cambridge, Cambridge, CB2 3EG, UK. gavin.kelsey@babraham.ac.uk.
Galvão AM; Molecular Mechanisms of Placental Invasion, Centro de Investigación Príncipe Felipe, Eduardo Primo Yúfera 3, 46012, Valencia, Spain. vperez@cipf.es.

Cell Mol Life Sci ; 81(1): 329, 2024 Aug 01.

Article em En | MEDLINE | ID: mdl-39090270

Assuntos

Decídua; Retardo do Crescimento Fetal; Leptina; Placenta; Transdução de Sinais; Animais; Feminino; Camundongos; Gravidez; Decídua/metabolismo; Decídua/patologia; Dieta Hiperlipídica/efeitos adversos; Retardo do Crescimento Fetal/metabolismo; Retardo do Crescimento Fetal/patologia; Leptina/metabolismo; Camundongos Endogâmicos C57BL; Camundongos Obesos; Obesidade/metabolismo; Obesidade/patologia; Placenta/metabolismo; Progesterona/metabolismo; Proteína Tirosina Fosfatase não Receptora Tipo 2/metabolismo; Proteína Tirosina Fosfatase não Receptora Tipo 2/genética; Fator de Transcrição STAT3/metabolismo; Células Estromais/metabolismo; Proteína 3 Supressora da Sinalização de Citocinas/metabolismo; Proteína 3 Supressora da Sinalização de Citocinas/genética

Palavras-chave

Decidua; Endometrium; Implantation; Leptin; Obesity; PTPN2; Placenta; SOCS3; STAT3

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Placenta / Transdução de Sinais / Leptina / Decídua / Retardo do Crescimento Fetal Limite: Animals / Pregnancy Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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