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Effect of different doses of Budesonide combined with Tiotropium bromide inhalation on elderly patients with chronic obstructive pulmonary disease.
Yu, Jianhong; Ni, Jianchao; Chen, Xindong; Fang, Yuanyuan; Fu, Suna.
Afiliação
  • Yu J; Jianhong Yu, Department of Geriatric, Affiliated Hospital of Shaoxing University, 999 Zhongxing South Road, Shaoxing, Zhejiang Province 312000, P.R. China.
  • Ni J; Jianchao Ni Department of Geriatric, Affiliated Hospital of Shaoxing University, 999 Zhongxing South Road, Shaoxing, Zhejiang Province 312000, P.R. China.
  • Chen X; Xindong Chen Department of Geriatric, Affiliated Hospital of Shaoxing University, 999 Zhongxing South Road, Shaoxing, Zhejiang Province 312000, P.R. China.
  • Fang Y; Yuanyuan Fang Department of Geriatric, Affiliated Hospital of Shaoxing University, 999 Zhongxing South Road, Shaoxing, Zhejiang Province 312000, P.R. China.
  • Fu S; Suna Fu Department of Geriatric, Affiliated Hospital of Shaoxing University, 999 Zhongxing South Road, Shaoxing, Zhejiang Province 312000, P.R. China.
Pak J Med Sci ; 40(7): 1338-1344, 2024 Aug.
Article em En | MEDLINE | ID: mdl-39092049
ABSTRACT

Objective:

To explore the clinical effect of various doses of Budesonide combined with Tiotropium bromide in the treatment of elderly patients with chronic obstructive pulmonary disease (COPD).

Methods:

Clinical data of elderly patients with COPD, admitted to Affiliated Hospital of Shaoxing University from April 2021 to February 2023, were retrospectively analyzed. Based on the dosage of Budesonide combined with Tiotropium bromide, patients were divided into Low-dose group (Budesonide = 1mg), Medium-dose group (Budesonide = 2mg), and High-dose group (Budesonide = 3mg). All groups were matched for age, gender, course of disease, and BMI. Patients treated with Tiotropium bromide alone were assigned to the Control group. The clinical effect, pulmonary function index level, symptom improvement, inflammatory factor index level and adverse reactions in all groups were analyzed and compared.

Results:

A total of 88 patients were included in this study with 22 patients in each group. The total efficacy of Medium-dose (90.91%) and High-dose group (90.91%) was significantly higher than that of Low-dose group (63.64%) and the Control group (59.09%) (P<0.05). After the treatment, levels of pulmonary function, symptom improvement and inflammatory factors in the High-dose and the Medium-dose groups were better than those in the Low-dose group and the Control group. Pulmonary function, symptom improvement and levels of inflammatory factors was significantly better in the Low-dose group compared to the Control group (P<0.05).

Conclusions:

Budesonide combined with tiotropium bromide is better than tiotropium bromide alone in the treatment of elderly patients with COPD. Compared with low (1mg) dosage, medium (2mg) and high (3mg) dosage of budesonide are more effective in improving lung function, alleviating symptoms, reducing inflammatory response,, and are not associated with increased rate of adverse reactions.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article