GABA system in the prefrontal cortex involved in psychostimulant addiction.
Cereb Cortex
; 34(8)2024 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-39098820
ABSTRACT
Drug addiction is a chronic and relapse brain disorder. Psychostimulants such as cocaine and amphetamine are highly addictive drugs. Abuse drugs target various brain areas in the nervous system. Recent studies have shown that the prefrontal cortex (PFC) plays a key role in regulating addictive behaviors. The PFC is made up of excitatory glutamatergic cells and gamma-aminobutyric acid (GABAergic) interneurons. Recently, studies showed that GABA level was related with psychostimulant addiction. In this review, we will introduce the role and mechanism of GABA and γ-aminobutyric acid receptors (GABARs) of the PFC in regulating drug addiction, especially in psychostimulant addiction.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Córtex Pré-Frontal
/
Transtornos Relacionados ao Uso de Substâncias
/
Ácido gama-Aminobutírico
/
Estimulantes do Sistema Nervoso Central
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article