Elucidation of Degradation Behavior of Barbiturates in Artificial Gastric Juice: Study on Degradability of Drugs in Stomach (V).
Chem Pharm Bull (Tokyo)
; 72(8): 747-750, 2024.
Article
em En
| MEDLINE
| ID: mdl-39111846
ABSTRACT
The gastric stability of eight barbiturates (BARs) (barbital, primidone, allobarbital, phenobarbital, cyclobarbital, pentobarbital, secobarbital, and thiobutabarbital (TBB)) was examined in artificial gastric juice using LC/UV detection. Among the eight BARs, only TBB was degraded at higher temperatures. Furthermore, the degradation product of TBB was isolated, structurally analyzed, and finally identified as 5-butan-2-yl-5-ethyl-1,3-diazinane-2,4,6-trione, also known as butabarbital. The study elucidated that butabarbital was formed by substituting the sulfur atom of the carbonyl group at the 2-position of TBB with an oxygen atom under acidic condition.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Barbitúricos
/
Suco Gástrico
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article