Association of choroidal thickness and blood flow features with asymmetric axial lengths in children with unilateral myopic anisometropia.
BMC Ophthalmol
; 24(1): 329, 2024 Aug 07.
Article
em En
| MEDLINE
| ID: mdl-39112923
ABSTRACT
BACKGROUND:
Considering that changes in the choroidal thickness are closely related to ocular growth, we studied the choroidal thickness (CT) and the blood flow features in children with unilateral myopic anisometropia (UMA) as well as investigating the relationship between choroidal changes and myopia.METHODS:
Subjective refractive, axial length (AL), and biometric parameters were measured in 98 UMA children (age 8-15 years). CT and choroidal blood-flow features, including the choroidal vessel volume (CVV), choroidal vascularity index (CVI), and choriocapillaris perfusion area (CCPA), were measured through swept-source optical coherence tomography angiography. The macular region was categorized into four concentric circles of diameters 0-1 mm (central fovea), 1-3 mm (parafovea), 3-6 mm (perifovea), and 6-9 mm (extended), and further categorized into superior (S), inferior (I), temporal (T), and nasal (N) quadrants.RESULTS:
The aforementioned four regions of myopic eyes displayed significantly lower CT, CVV, and CVI than those of non-myopic eyes. CCPA changes differed across different regions of both the eyes (parts of N and T quadrants). There was an inverse association between CT and the interocular AL difference (central and other regions S, T quadrant). No correlation was noted between CVV and CVI with interocular AL difference. CT and CVV were positively correlated in the 0-6-mm macular region of myopic eyes (Spearman correlation coefficient = 0.763, P < 0.001).CONCLUSIONS:
In UMA children, CCT and blood flow may be related to myopia progression. A robust correlation between CT and CVV in the 0-6-mm macular region and reduced CT and diminished blood flow indicated an association with myopia.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fluxo Sanguíneo Regional
/
Anisometropia
/
Corioide
/
Tomografia de Coerência Óptica
/
Comprimento Axial do Olho
/
Miopia
Limite:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article