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Genome Wide Conditional Mouse Knockout Resources.
Kaloff, C; Anastassiadis, K; Ayadi, A; Baldock, R; Beig, J; Birling, M-C; Bradley, A; Brown, S; Bürger, A; Bushell, W; Chiani, F; Collins, F S; Doe, B; Eppig, J T; Finnel, R H; Fletcher, C; Flicek, P; Fray, M; Friedel, R H; Gambadoro, A; Gates, H; Hansen, J; Herault, Y; Hicks, G G; Hörlein, A; Hrabé de Angelis, M; Iyer, V; de Jong, P J; Koscielny, G; Kühn, R; Liu, P; Lloyd, K C; Lopez, R G; Marschall, S; Martínez, S; McKerlie, C; Meehan, T; von Melchner, H; Moore, M; Murray, S A; Nagy, A; Nutter, Lmj; Pavlovic, G; Pombero, A; Prosser, H; Ramirez-Solis, R; Ringwald, M; Rosen, B; Rosenthal, N; Rossant, J.
Afiliação
  • Kaloff C; Institute of Developmental Genetics, Helmholtz Zentrum Muenchen, D-85764 Neuherberg, Germany.
  • Anastassiadis K; Biotechnology Center (BIOTEC) of the Technische Universität Dresden, 01307 Dresden, Germany.
  • Ayadi A; CELPHEDIA, PHENOMIN, Institut Clinique de la Souris (ICS), CNRS, INSERM, University of Strasbourg, 1 rue Laurent Fries, F-67404 Illkirch-Graffenstaden, France.
  • Baldock R; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, College of Medicine and Veterinary Medicine, Edinburgh, Scotland EH4 2XU, UK.
  • Beig J; Institute of Developmental Genetics, Helmholtz Zentrum Muenchen, D-85764 Neuherberg, Germany.
  • Birling MC; CELPHEDIA, PHENOMIN, Institut Clinique de la Souris (ICS), CNRS, INSERM, University of Strasbourg, 1 rue Laurent Fries, F-67404 Illkirch-Graffenstaden, France.
  • Bradley A; The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB101HH, UK.
  • Brown S; Mammalian Genetics Unit, MRC Harwell, Harwell Science and Innovation Campus, Oxfordshire, OX110RD, UK.
  • Bürger A; Institute of Developmental Genetics, Helmholtz Zentrum Muenchen, D-85764 Neuherberg, Germany.
  • Bushell W; The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB101HH, UK.
  • Chiani F; Istituto di Biologia Cellulare, Consiglio Nazionale delle Ricerche (CNR), Monterotondo-Scalo, I-00015 Rome, Italy.
  • Collins FS; Office of the Director, National Institutes of Health, Bethesda, Maryland, 20892, USA.
  • Doe B; The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB101HH, UK.
  • Eppig JT; The Jackson Laboratory, Bar Harbor, ME 04609, USA.
  • Finnel RH; The Texas A&M Institute for Genomic Medicine, College Station, Texas, 77843-4485 USA; University of Texas at Austin, Austin, Texas, 78712, USA.
  • Fletcher C; National Institutes of Health, Bethesda, Maryland, 20205, USA.
  • Flicek P; European Bioinformatics Institute (EBI), Hinxton, Cambridge, CB101ST, UK.
  • Fray M; Mammalian Genetics Unit, MRC Harwell, Harwell Science and Innovation Campus, Oxfordshire, OX110RD, UK.
  • Friedel RH; Institute of Developmental Genetics, Helmholtz Zentrum Muenchen, D-85764 Neuherberg, Germany.
  • Gambadoro A; Istituto di Biologia Cellulare, Consiglio Nazionale delle Ricerche (CNR), Monterotondo-Scalo, I-00015 Rome, Italy.
  • Gates H; Mammalian Genetics Unit, MRC Harwell, Harwell Science and Innovation Campus, Oxfordshire, OX110RD, UK.
  • Hansen J; Institute of Developmental Genetics, Helmholtz Zentrum Muenchen, D-85764 Neuherberg, Germany.
  • Herault Y; Institut de Génétique et de Biologie Moléculaire et Cellulaire, Université de Strasbourg, 1 rue Laurent Fries, 67404 Illkirch, France.
  • Hicks GG; Centre National de la Recherche Scientifique, UMR7104, Illkirch, France.
  • Hörlein A; Institut National de la Santé et de la Recherche Médicale, U964, Illkirch, France.
  • Hrabé de Angelis M; Université de Strasbourg, 1 rue Laurent Fries, 67404 Illkirch, France.
  • Iyer V; University of Manitoba, Manitoba Institute of Cell Biology, Winnipeg, MB, R3EOV9, Canada.
  • de Jong PJ; Institute of Developmental Genetics, Helmholtz Zentrum Muenchen, D-85764 Neuherberg, Germany.
  • Koscielny G; Institute of Experimental Genetics, Helmholtz Zentrum Muenchen, D-85764 Neuherberg, Germany.
  • Kühn R; The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB101HH, UK.
  • Liu P; Children's Hospital Oakland Research Institute, CHORI, Oakland, CA, 94609, USA.
  • Lloyd KC; European Bioinformatics Institute (EBI), Hinxton, Cambridge, CB101ST, UK.
  • Lopez RG; Institute of Developmental Genetics, Helmholtz Zentrum Muenchen, D-85764 Neuherberg, Germany.
  • Marschall S; The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB101HH, UK.
  • Martínez S; Mouse Biology Program, School of Veterinary Medicine, University of California, Davis, California 95616, USA.
  • McKerlie C; Instituto de Neurociencias (UMH-CSIC), San Juan de Alicante.
  • Meehan T; Institute of Experimental Genetics, Helmholtz Zentrum Muenchen, D-85764 Neuherberg, Germany.
  • von Melchner H; Instituto de Neurociencias (UMH-CSIC), San Juan de Alicante.
  • Moore M; The Centre for Phenogenomics and Translation Medicine, The Hospital for Sick Children, Toronto, CANADA.
  • Murray SA; European Bioinformatics Institute (EBI), Hinxton, Cambridge, CB101ST, UK.
  • Nagy A; Department of Molecular Haematology, University of Frankfurt Medical School, 60590 Frankfurt am Main, Germany.
  • Nutter L; IMPC, San Anselmo, California, US.
  • Pavlovic G; The Jackson Laboratory, Bar Harbor, ME 04609, USA.
  • Pombero A; Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Joseph and Wolf Lebovic Health Complex, Toronto, ON, M5G1X5, Canada.
  • Prosser H; The Centre for Phenogenomics and Translation Medicine, The Hospital for Sick Children, Toronto, CANADA.
  • Ramirez-Solis R; CELPHEDIA, PHENOMIN, Institut Clinique de la Souris (ICS), CNRS, INSERM, University of Strasbourg, 1 rue Laurent Fries, F-67404 Illkirch-Graffenstaden, France.
  • Ringwald M; Instituto de Neurociencias (UMH-CSIC), San Juan de Alicante.
  • Rosen B; The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB101HH, UK.
  • Rosenthal N; The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB101HH, UK.
  • Rossant J; The Jackson Laboratory, Bar Harbor, ME 04609, USA.
Drug Discov Today Dis Models ; 20: 3-12, 2016.
Article em En | MEDLINE | ID: mdl-39132094
ABSTRACT
The International Knockout Mouse Consortium (IKMC) developed high throughput gene trapping and gene targeting pipelines that produced mostly conditional mutations of more than 18,500 genes in C57BL/6N mouse embryonic stem (ES) cells which have been archived and are freely available to the research community as a frozen resource. From this unprecedented resource more than 6,000 mutant mouse strains have been produced by the IKMC and mostly the International Mouse Phenotyping Consortium (IMPC). In addition, a cre-driver resource was established including 250 inducible cre-driver mouse strains in a C57BL/6 background. Complementing the cre-driver resource, a collection of comprising 27 cre-driver rAAVs has also been produced. The resources can be easily accessed at the IKMC/IMPC web portal (www.mousephenotype.org). The IKMC/IMPC resource is a standardized reference library of mouse models with defined genetic backgrounds that enables the analysis of gene-disease associations in mice of different genetic makeup and should therefore have a major impact on biomedical research.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2016 Tipo de documento: Article