Efficacy of escalating therapy with brentuximab vedotin-AVD in advanced stage Hodgkin lymphoma patients with positive interim positron emission tomography after ABVD.
Hematol Oncol
; 42(5): e3299, 2024 Sep.
Article
em En
| MEDLINE
| ID: mdl-39132926
ABSTRACT
Patients with advanced-stage Hodgkin lymphoma treated with ABVD who have a positive interim FDG-PET (iPET) have a poor prognosis. Escalation to BEACOPP has been shown to improve progression-free survival (PFS). However, randomized trials are lacking to determine the best strategy for intensification. We report on A-AVD escalation treatment outcomes for 15 iPET-positive patients post-ABVD. Overall response and complete response rates were 80% and 60%, respectively. Four patients underwent salvage therapy followed by autologous stem cell transplantation. At a median 17-month follow-up, all patients are alive, 87% in complete remission, and 1-year PFS was 57.8%. For patients ineligible for BEACOPP due to age, comorbidities, or preference, A-AVD escalation may be a viable alternative.
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Base de dados:
MEDLINE
Assunto principal:
Vimblastina
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Bleomicina
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Doença de Hodgkin
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Protocolos de Quimioterapia Combinada Antineoplásica
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Doxorrubicina
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Dacarbazina
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Tomografia por Emissão de Pósitrons
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Brentuximab Vedotin
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article