Unveiling thiol biomarkers: Glutathione and cysteamine.
Clin Chim Acta
; 563: 119915, 2024 Sep 15.
Article
em En
| MEDLINE
| ID: mdl-39134217
ABSTRACT
The physiological and clinical importance of Glutathione and Cysteamine is emphasized by their participation in a range of conditions, such as diabetes, cancer, renal failure, Parkinson's disease, and hypothyroidism. This necessitates the requirement for accessible, expedited, and cost-efficient testing that can facilitate clinical diagnosis and treatment options. This article examines numerous techniques used to detect both glutathione and cysteamine. The discussed methods include electroanalytical techniques such as voltammetry and amperometry, which are examined for their sensitivity and ability to provide real-time analysis. Furthermore, this study investigates the accuracy of gas chromatography-mass spectrometry (GC-MS) and high-performance liquid chromatography (HPLC) in measuring the concentrations of glutathione and cysteamine. Additionally, the potential of new nanotechnology-based methods, such as plasmonic nanoparticles and quantum dots, to improve the sensitivity of detecting glutathione and cysteamine is emphasized.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Biomarcadores
/
Cisteamina
/
Glutationa
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article