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Masks As a New Hotspot for Antibiotic Resistance Gene Spread: Reveal the Contribution of Atmospheric Pollutants and Potential Risks.
Wang, Yanjie; Wang, Qi; Zhang, Guodong; Li, Yutong; Guo, He; Zhou, Jian; Wang, Tiecheng; Jia, Hanzhong; Zhu, Lingyan.
Afiliação
  • Wang Y; College of Natural Resources and Environment, Northwest A&F University, Yangling, Shaanxi Province 712100, PR China.
  • Wang Q; Key Laboratory of Plant Nutrition and the Agri-environment in Northwest China, Ministry of Agriculture, Yangling Shaanxi 712100, PR China.
  • Zhang G; College of Natural Resources and Environment, Northwest A&F University, Yangling, Shaanxi Province 712100, PR China.
  • Li Y; Key Laboratory of Plant Nutrition and the Agri-environment in Northwest China, Ministry of Agriculture, Yangling Shaanxi 712100, PR China.
  • Guo H; College of Natural Resources and Environment, Northwest A&F University, Yangling, Shaanxi Province 712100, PR China.
  • Zhou J; Key Laboratory of Plant Nutrition and the Agri-environment in Northwest China, Ministry of Agriculture, Yangling Shaanxi 712100, PR China.
  • Wang T; College of Natural Resources and Environment, Northwest A&F University, Yangling, Shaanxi Province 712100, PR China.
  • Jia H; Key Laboratory of Plant Nutrition and the Agri-environment in Northwest China, Ministry of Agriculture, Yangling Shaanxi 712100, PR China.
  • Zhu L; College of Biology and the Environment, Nanjing Forestry University, Nanjing 210037, China.
Environ Sci Technol ; 58(36): 16100-16111, 2024 Sep 10.
Article em En | MEDLINE | ID: mdl-39137285
ABSTRACT
The consumption of disposable surgical masks (DSMs) considerably increased during the coronavirus pandemic in 2019. Herein, we explored the spread of antibiotic resistance genes (ARGs) and the potential risks of antibiotic resistant bacteria (ARB) on DSMs. At environmentally relevant concentrations, the conjugate transfer frequency (CTF) of ARGs increased by 1.34-2.37 folds by 20 µg/m3 of atmospheric water-soluble inorganic ions (WSIIs), and it increased by 2.62-2.86 folds by 80 ng/m3 of polycyclic aromatic hydrocarbons (PAHs). Total suspended particulates (TSP) further promoted the CTF in combination with WSIIs or PAHs. Under WSII and PAH exposure, gene expression levels related to oxidative stress, cell membrane, and the adenosine triphosphate (ATP) were upregulated. WSIIs predominantly induced cellular contact, while PAHs triggered ATP formation and membrane damage. Molecular dynamics simulations showed that WSIIs and PAHs reduced membrane lipid fluidity and increased membrane permeability through interactions with the phosphatidylcholine bilayer. DSM filtering performance decreased, and the CTF of ARGs increased with the wearing time. The gut simulator test showed that ARB disrupted the human gut microbial community and increased total ARG abundance but did not change the ARG abundance carried by ARB themselves. A mathematical model showed that long-term WSII and PAH exposure accelerated ARG dissemination in DSMs.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hidrocarbonetos Policíclicos Aromáticos / Máscaras Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hidrocarbonetos Policíclicos Aromáticos / Máscaras Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article