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Intervention portfolios analysis of Plasmodium vivax control in central China.
Bi, Bo; Wu, Logan; Liu, Ying; Zhou, Xiao-Nong; Shen, Tianren; Cao, Li; White, Michael; Yang, Guo-Jing.
Afiliação
  • Bi B; NHC Key Laboratory of Tropical Disease Control, School of Tropical Medicine, School of Public Health, Hainan Medical University, Haikou, People's Republic of China.
  • Wu L; Department of Population Health and Immunity, Walter and Eliza Hall Institute, Melbourne, Australia.
  • Liu Y; Department of Medical Biology, University of Melbourne, Melbourne, Australia.
  • Zhou XN; Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Shen T; Henan Center for Disease Control and Prevention, Zhengzhou, Henan, People's Republic of China.
  • Cao L; National Institute of Parasitic Diseases at Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • White M; Infection Medicine, Deanery of Biomedical Sciences, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, Scotland, UK.
  • Yang GJ; Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Zhejiang University, Haining, China.
Malar J ; 23(1): 242, 2024 Aug 13.
Article em En | MEDLINE | ID: mdl-39138510
ABSTRACT

BACKGROUND:

The effects of a diverse spectrum of malaria interventions were evaluated through a deterministic Plasmodium vivax transmission model. This approach aimed to provide theoretical evidence of the performance of these interventions once implemented for achieving malaria elimination.

METHODS:

An integrated intervention portfolio, including mass drug administration, insecticide treatment, and untreated bed nets, was analyzed through modeling. Additionally, data-driven calibration was implemented to infer coverages that effectively reproduced historical malaria patterns in China from 1971 to 1983.

RESULTS:

MDA utilizing primaquine emerged as the most effective single intervention, achieving a 70% reduction in malaria incidence when implemented at full coverage. Furthermore, a strategic combination of MDA with primaquine, chloroquine, untreated bed nets, and seasonal insecticide treatments effectively eradicated malaria, attaining elimination at a coverage level of 70%. It was conclusively demonstrated that an integrated approach combining MDA and vector control measures is essential for the successful elimination of malaria.

CONCLUSION:

High coverage of mass drug administration with primaquine and chloroquine before transmission was the key driver of the malaria decline in China from 1971 to 1983. The best-fit intervention coverage combinations derived from calibration are provided as a reference for malaria control in other countries.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Malária Vivax / Antimaláricos Limite: Humans País como assunto: Asia Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Malária Vivax / Antimaláricos Limite: Humans País como assunto: Asia Idioma: En Ano de publicação: 2024 Tipo de documento: Article