Multi-institutional analysis of extracranial oligometastatic colorectal cancer patients treated with stereotactic body radiation therapy: TROD 02-008 study.
Strahlenther Onkol
; 2024 Aug 19.
Article
em En
| MEDLINE
| ID: mdl-39158748
ABSTRACT
PURPOSE:
To investigate the treatment outcomes of extracranial oligometastatic colorectal cancer (CRC) patients treated with stereotactic body radiotherapy (SBRT). MATERIALS ANDMETHODS:
The clinical data of 388 extra-cranial oligometastatic CRC (≤â¯5 lesions) patients and 463 lesions treated with SBRT at 19 cancer institutions were retrospectively analyzed. The prognostic factors predicting overall survival (OS), progression-free survival (PFS), and local control (LC) were assessed in uni- and multivariable analyses.RESULTS:
The median age was 62 years (range, 29-92 years). The majority of the patients (90.5%) received surgery and systemic treatment for their primary tumor, had ≤â¯2 metastasis (83.3%), had single organ involvement (90.3%), and staged using flouro-deoxyglucose positron emission tomography (FDG-PET/CT) (76%). The median fraction and total radiation doses were 10â¯Gy (range 6-34â¯Gy) and 50â¯Gy (range 8-64â¯Gy), respectively, delivered in a median of 4 fractions (range 1-8). The median follow-up time for the entire cohort was 30.7 months (interquartile range 27.0-34.3 months). The 3year OS, PFS, and LC rates were 64.0%, 42.3%, and 72.7%, respectively. The 3year LC rate was significantly higher in patients receiving BED10â¯≥â¯100â¯Gy than those receiving BED10â¯<â¯100â¯Gy (76.0% vs. 67.3%; pâ¯= 0.04). The 3year PFS and OS rates were higher in patients receiving BED10â¯≥â¯100â¯Gy than those receiving BED10â¯<â¯100â¯Gy (33.2% vs. 25.2%; pâ¯= 0.03; 53.7% vs. 44.8%; pâ¯= 0.02). Single metastasis and complete response after SBRT were independent prognostic factors for survival in multivariable analysis.CONCLUSIONS:
In this multi-center study, we demonstrated that SBRT is an effective treatment option of metastatic lesions in oligometastatic CRC patients by providing promising LC rates. Higher SBRT doses beyond BED10â¯≥â¯100â¯Gy were associated with improved LC and survival. LC of treated lesion and lower tumor burden after SBRT were associated with better outcomes.
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Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article