[Research progress on the pyroptosis mediated by the NLRP3 inflammasome in the pathology of ischemic stroke].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
; 40(7): 648-654, 2024 Jul.
Article
em Zh
| MEDLINE
| ID: mdl-39179409
ABSTRACT
Ischemic stroke is one of the diseases which pose a significant threat to human health. Recent studies have suggested that programmed cell death plays an important role in brain tissues affected by ischemia and hypoxia. Pyroptosis, which is characterized by both apoptosis and necrosis, is mediated by activation of inflammasomes, such as NOD-like receptor family, pyrin domain containing 3 (NLRP3). Pyroptosis, which depends on caspase-1 activation and the release of pro-inflammatory cytokines, such as Interleukin 1ß and Interleukin 18, plays a vital role in regulating cell survival and death following ischemic injury. Previous studies have shown that pyroptosis is closely related to the activation of the NLRP3 inflammasome in ischemic stroke tissues. This distinctive form of cell death mainly occurs in microglia, neurons, astrocytes and endothelial cells. This paper reviews the role of pyroptosis mediated by inflammasomes in ischemic stroke, discussing the targets and substances that affect the activation of the NLRP3 inflammasome, which can provide a new theoretical and experimental basis for the treatment of ischemic stroke.
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Base de dados:
MEDLINE
Assunto principal:
Inflamassomos
/
Piroptose
/
Proteína 3 que Contém Domínio de Pirina da Família NLR
/
AVC Isquêmico
Limite:
Animals
/
Humans
Idioma:
Zh
Ano de publicação:
2024
Tipo de documento:
Article